Use Gold Film Electrode Determination Metronidazole Presence Acetaminophen

This study, it was placed to provide a sensitive, easy and selective method for designing Nano-porous gold film electrode (NPGF) electrode for simultaneous measurement of metronidazole (MT) and acetaminophen (AC). For this purpose, the NPGF electrode surface was changed with chitosan (CS) and poly pyrrole (PPY) by electrochemical method, and then CS and PPY qualifyed NPGF (PPY-CS-NPGF) electrode were used to measure these drugs. skiming electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) are used for the characterization of the maked PPY-CS-NPGF electrode. Using cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and chronoamperometry, the electrochemical behavior of MT was investigated with the modified electrode. By differential pulse voltammetry, linear ranges of concentration 0-100 μM with linear coefficients of 0 and a detection limit of 0 μM were holded for MT an electrochemical sensor was used to measure MT in a real sample, which returned acceptable results. PPY-CS-NPGF electrodes have a wide linear range, high selectivity, sensitivity and stability and can be used successfully to determine these drugs.

Dietary chitosan modulates the growth performance, body composition and nonspecific immunity of juvenile yellow catfish (Pelteobagrus fulvidraco).This study inquired the effects of tiping different concentrations of chitosan on the growth performance, body composition and non-specific immune function of juvenile yellow catfish (Pelteobagrus fulvidraco). Four varietys of experimental dietings were respectively maked by toting 0 (control group), 5, 10 and 15 g/kg of chitosan to the basal feed and fed to juvenile yellow catfish for 8 workweeks. Results show that the body weight gain rate, specific growth rate, survival rate, body protein content, serum superoxide dismutase activity, catalase activity, glutathione peroxidise activity, lysozyme activity and disease resistance ability against Aeromonas hydrophila of the experimental group with chitosan imparted to its diet were significantly higher than those of the control group optimally by 36 %, 14 %, 9 %, 8 %, 50 %, 33 %, 21 %, 40 %, 41 %, and 79 %, respectively (P < 0). No significant disputes in feed efficiency among all groupings (P > 0) were watched. The optimum dose of dietary chitosan required for the maximum growth of juvenile yellow catfish was 8 g/kg totaling an appropriate amount of chitosan (8 g/kg) to the feed of yellow catfish can significantly improve its growth performance, ameliorate body composition and enhance its non-specific immunity.Curcumin-laded multifunctional chitosan gold nanoparticles: An heightened PDT/PTT dual-modal phototherapeutic and pH-responsive antimicrobial agent.

Overuse of antibiotics has led to the emergence of multidrug resistant (MDR) bacteria.. Photothermal (PTT) and photodynamic therapy (PDT) have may be effective choices for antibiotics in the treatment of bacterial infections. In this study, established on chitosan (CS)-coated gold nanoparticles, a pH stimulus-responsive drug delivery system was geted, which can anchor to the cell membrane for photodynamic therapy and photothermal therapy, and enhance the therapeutic potential of curcumin (Cur). Release experiments evinced that AuNPs/CS-Cur nanocomposites ejected curcumin in a pH-dependent manner, which may facilitate the drug to be delivered to the acidic bacterial infection environment.  Health Benefits  as the outer layer continued on gold nanoparticles could improve the dispersibility of Cur in aqueous solution, gold nanoparticles prevent rapid photobleaching of curcumin, thus controling the yield of singlet oxygen under irradiation, and enhance the electrostatic binding with bacteria cell membrane. Under light terms, AuNPs/CS-Cur can produce a large amount of reactive oxygen species and heat to kill S.

aureus and E. coli. Compared with free Cur-mediated PDT, the complex significantly meliorated the synergistic PTT/PDT photoinactivation ability against S. aureus and E. coli.