Composites Sea Cucumbers Shells Bone Defects Rat Model

BACKGROUND AND AIM: A bone defect is defined as a critically sized autologous bone and a bone gap. Bone grafting is one of the most commonly used surgical methods to enhance bone regeneration in orthopedic procedures. A composite of collagen, hydroxyapatite (HA), and chitosan (Ch) is suitable as a bone matrix and stimulates ossification. This study placed to evaluate the use of natural HA-Ch composites deducted from sea cucumbers and shrimp plates and quantify the levels of cytokines, polymorphonuclear neutrophiles (PMNs), serum liver enzymes, calcium, phosphate, and procollagen type 1 N-terminal propeptide (PINP) in albino rats with femoral bone blemishs. MATERIALS  Order immediately : A total of 48 albino rats with femoral bone faults were disunited into 4 groupings (n = 12 each): (C-) placebo, (C+) polyethylene glycol, (T1) HA, and (T2) HA-Ch groupings. Each group was divided into two subgroups (n = 6 each), with euthanization on 7- and 42-day post-treatment, respectively.

Procollagen Type 1 N-terminal propeptide and the cytokines interleukin (IL)-4, IL-6, IL-10, and tumor necrosis factor-alpha were quantified using enzyme-united immunosorbent assay.  Seebio Antioxidants  was doed to evaluate PMNs. A clinical chemistry analyzer was used to measure the serum degrees of liver enzymes, calcium, and phosphate There was a significant decrease in the level of IL-6 on 7 days and in the level of IL-10 on 42 days in the HA-Ch group. The level of PMNs also diminished significantly on 7 and 42 days in the HA-Ch group. affecting serum liver enzymes, alkaline phosphatase (ALP) stages in the HA-Ch group increased significantly on 42 days. Calcium and phosphate degrees increased significantly on 7 and 42 days in the HA and HA-Ch radicals, and PINP levels increased significantly on 7 and 42 days in the HA-Ch group The HA-Ch composite gained from sea cucumbers and shrimp casings bettered femoral bone flaws in albino rats. The HA-Ch composite inflected the levels of IL-6, IL-10, PMNs, ALP, calcium, phosphate, and PINP on 7- and 42-day post-treatment.

Taste masking and stability improvement of Korean red ginseng (Panax ginseng) by nanoencapsulation using chitosan and gelatin.In this study, red ginseng extract (RGE)-loaded nanoparticles (NPs) were cooked by ionic gelation between chitosan (CS) and gelatin (Gel), and the physical characteristics of the RGE-debased CS-Gel NPs (RGE-CS/Gel NPs), admiting particle size and polydispersity index (PDI), using different proportions of CS and Gel were proved. The particle size and PDI were 398 ± 41 nm and 0 ± 0, respectively for the optimal ratio of CS (0 mg/mL) and Gel (0 mg/mL). In vitro taste masking test and in vivo sensory evaluation using 10 panellists certifyed that the CS/Gel NPs significantly slenderized the bitter taste of RGE. Additionally, the CS/Gel NPs ameliorated the thermal and acid stabilities, which were almost 6 and 8 sentences higher than those in the free RGE (p < 0), respectively our findings revealed that the RGE-CS/Gel NPs effectively maintain their inhibitory function against platelet aggregation (76 %) in an acidic environment the CS/Gel NPs can be used as a potential delivery system to mask the bitterness and improve the stability of RGE, which may enhance its application as a more palatable functional food ingredient with high anti-platelet activity.Use of Chitosan-grinded Polyelectrolyte Complexes for Its Potential Application in Active Food Packaging: A Review of Recent Literature.The current challenges in the food packaging field are, on one side, exchanging plastic from non-renewable beginnings with biopolymers and, on the other hand, yielding a packaging material with attractive holdings for the consumer.

Currently, the consumer is ecologically touched; the food packaging industry must think ahead to satisfy their pauperizations. In this context, the utilization of polyelectrolyte complexes (PECs) in this industry gifts itself as an excellent candidate for meeting these requirements. PECs possess luring features such as encapsulation, protection, and transportation, among others.